S&P 500: 681.27 -1.5% NASDAQ 100: 600.64 -2.0% Dow Jones: 494.67 -1.3%

Ionis Pharmaceuticals, Inc.

IONS Healthcare
$81.78 $-2.58 (-3.05%)
Market Cap: $13.25 B
Gurus Holding
9
Popularity Rank
#520
% of Shares Held
2.10%
Net Activity (Q3 2025)
-$10.33 M

Guru Ownership Trend

Guru Analysis for Ionis Pharmaceuticals, Inc. (IONS)

Ionis Pharmaceuticals, Inc. (IONS), a key player in the Healthcare sector, continues to attract institutional attention.

As of Q4 2025, a total of 9 Super Investors (Gurus) hold positions in the company, with a combined stake valued at approximately $277.89 M.

Top institutional holders include Tweedy Browne and Catherine Wood.

Notably, Tweedy Browne has expressed high conviction in this stock, allocating 15.74% of their equity portfolio to it.

Institutional sentiment is currently Slightly Bearish. This is evidenced by a $10.33 M net outflow during the quarter.

Recent activity highlights Ken Fisher who dramatically increased their stake. Conversely, Renaissance Technologies reduced exposure by 54.1%.

Key Holders

Top 5 by Value

Top 5 by Conviction

Recent Activity Breakdown (Q3 2025)

+$19.64 M
Total Buy Value
New Buys 3
Additions 4
-$29.97 M
Total Sell Value
Reductions 2
Sold Out 1

Guru Consensus (Q3 2025)

Based on recent activity
Net Sellers
3
Net Buyers
7

FAQs for Ionis Pharmaceuticals, Inc. (IONS)

Major holders include Tweedy Browne ($195 M), Catherine Wood ($33.46 M), Renaissance Technologies ($17.69 M). According to the latest reported data, 9 tracked investment managers collectively hold approximately 3.4 M shares.

According to the latest 13F reporting period, sentiment appears Bearish (Net Selling). There was a net outflow of $10.33 M, with 7 managers increasing positions and 3 managers reducing holdings.

During the most recent reporting period, 2 managers trimmed their positions, while 1 fully exited IONS. The total reported sell value was $29.97 M.

Yes, 3 managers opened new positions in IONS, and 4 increased their existing holdings. The total reported buy value was $19.64 M.

Portfolio Manager % Portfolio Activity Shares Value Report Date
15.74% Reduce -15.0% 2,464,930 $195 M Q4 2025
0.22% Reduce -33.0% 422,968 $33.46 M Q4 2025
0.03% Reduce -54.1% 223,607 $17.69 M Q4 2025
0.00% Add 2180.4% 141,615 $11.2 M Q4 2025
0.02% Add 395.6% 50,395 $3.99 M Q4 2025
0.01% New Buy 43,578 $2.85 M Q3 2025
0.01% Add 125.2% 32,152 $2.1 M Q3 2025
0.01% Reduce -4.2% 11,952 $945,522 Q4 2025
0.00% New Buy 6,815 $438,749 Q3 2025
Date
Insider Name
Transaction
Value
Shares
Position / Chg
SEC Form