Guru Ownership Trend
Guru Analysis for Spyre Therapeutics, Inc. (SYRE)
Spyre Therapeutics, Inc. (SYRE), a key player in the Healthcare sector, continues to attract institutional attention.
As of Q4 2025, a total of 3 Super Investors (Gurus) hold positions in the company, with a combined stake valued at approximately $32.84 M.
Top institutional holders include Steven Cohen and Cliff Asness.
Institutional sentiment is currently Slightly Bearish. This is evidenced by a $1.22 M net outflow during the quarter.
Recent activity highlights Steven Cohen who opened a new position.
Key Holders
Top 5 by Value
Top 5 by Conviction
Recent Activity Breakdown (Q4 2025)
Guru Consensus (Q4 2025)
FAQs for Spyre Therapeutics, Inc. (SYRE)
Major holders include Steven Cohen ($21.7 M), Cliff Asness ($583,783), Paul Tudor Jones ($331,761). According to the latest reported data, 3 tracked investment managers collectively hold approximately 690,298 shares.
According to the latest 13F reporting period, sentiment appears Bearish (Net Selling). There was a net outflow of $1.22 M, with 3 managers increasing positions and 1 managers reducing holdings.
During the most recent reporting period, 0 managers trimmed their positions, while 1 fully exited SYRE. The total reported sell value was $23.28 M.
Yes, 2 managers opened new positions in SYRE, and 1 increased their existing holdings. The total reported buy value was $22.06 M.