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Protagonist Therapeutics, Inc.

PTGX Healthcare
$103.02 +$5.94 (6.11%)
Market Cap: $6.57 B
Gurus Holding
10
Popularity Rank
#434
% of Shares Held
0.63%
Net Activity (Q4 2025)
-$56.43 M

Guru Ownership Trend

Guru Analysis for Protagonist Therapeutics, Inc. (PTGX)

Protagonist Therapeutics, Inc. (PTGX), a key player in the Healthcare sector, continues to attract institutional attention.

As of Q4 2025, a total of 10 Super Investors (Gurus) hold positions in the company, with a combined stake valued at approximately $41.61 M.

Top institutional holders include Stanley Druckenmiller and George Soros.

Institutional sentiment is currently Bearish. This is evidenced by a $56.43 M net outflow during the quarter.

Recent activity highlights George Soros who opened a new position. Conversely, Jefferies Group reduced exposure by 99.4%.

Key Holders

Top 5 by Value

$8.73 M
$5.69 M
$1.89 M
$1.48 M

Top 5 by Conviction

Recent Activity Breakdown (Q4 2025)

+$15.81 M
Total Buy Value
New Buys 4
Additions 0
-$72.24 M
Total Sell Value
Reductions 4
Sold Out 0

Guru Consensus (Q4 2025)

Based on recent activity
Net Sellers
4
Net Buyers
4

FAQs for Protagonist Therapeutics, Inc. (PTGX)

Major holders include Stanley Druckenmiller ($13.95 M), George Soros ($8.73 M), Ken Fisher ($5.69 M). According to the latest reported data, 10 tracked investment managers collectively hold approximately 403,837 shares.

According to the latest 13F reporting period, sentiment appears Bearish (Net Selling). There was a net outflow of $56.43 M, with 4 managers increasing positions and 4 managers reducing holdings.

During the most recent reporting period, 4 managers trimmed their positions, while 0 fully exited PTGX. The total reported sell value was $72.24 M.

Yes, 4 managers opened new positions in PTGX, and 0 increased their existing holdings. The total reported buy value was $15.81 M.

Portfolio Manager % Portfolio Activity Shares Value Report Date
0.31% 159,700 $13.95 M Q4 2025
0.10% New Buy 100,000 $8.73 M Q4 2025
0.00% New Buy 65,114 $5.69 M Q4 2025
0.01% Reduce -2.7% 21,595 $1.89 M Q4 2025
0.02% 16,989 $1.48 M Q4 2025
0.27% Reduce -40.0% 12,600 $1.1 M Q4 2025
0.00% New Buy 8,167 $713,306 Q4 2025
0.00% New Buy 7,718 $674,090 Q4 2025
0.00% Reduce -18.9% 6,954 $607,362 Q4 2025
0.00% Reduce -99.4% 5,000 $436,700 Q4 2025
Date
Insider Name
Transaction
Value
Shares
Position / Chg
SEC Form