S&P 500: 662.29 -0.6% NASDAQ 100: 593.72 -0.6% Dow Jones: 466.41 -0.2%

Praxis Precision Medicines, Inc.

PRAX Healthcare
$293.95 $-9.42 (-3.11%)
Market Cap: $8.19 B
Gurus Holding
4
Popularity Rank
#2181
% of Shares Held
2.14%
Net Activity (Q4 2025)
-$274.98 M

Guru Ownership Trend

Guru Analysis for Praxis Precision Medicines, Inc. (PRAX)

Praxis Precision Medicines, Inc. (PRAX), a key player in the Healthcare sector, continues to attract institutional attention.

As of Q4 2025, a total of 4 Super Investors (Gurus) hold positions in the company, with a combined stake valued at approximately $175.14 M.

Top institutional holders include Steven Cohen and Renaissance Technologies.

Institutional sentiment is currently Bearish. This is evidenced by a $274.98 M net outflow during the quarter.

Recent activity highlights Renaissance Technologies who opened a new position. Conversely, Steven Cohen reduced exposure by 67.1%.

Key Holders

Top 5 by Value

Top 5 by Conviction

Recent Activity Breakdown (Q4 2025)

+$21.56 M
Total Buy Value
New Buys 1
Additions 1
-$296.54 M
Total Sell Value
Reductions 2
Sold Out 1

Guru Consensus (Q4 2025)

Based on recent activity
Net Sellers
3
Net Buyers
2

FAQs for Praxis Precision Medicines, Inc. (PRAX)

Major holders include Steven Cohen ($145.11 M), Renaissance Technologies ($19.52 M), Cliff Asness ($8.5 M). According to the latest reported data, 4 tracked investment managers collectively hold approximately 595,804 shares.

According to the latest 13F reporting period, sentiment appears Bearish (Net Selling). There was a net outflow of $274.98 M, with 2 managers increasing positions and 3 managers reducing holdings.

During the most recent reporting period, 2 managers trimmed their positions, while 1 fully exited PRAX. The total reported sell value was $296.54 M.

Yes, 1 managers opened new positions in PRAX, and 1 increased their existing holdings. The total reported buy value was $21.56 M.

Portfolio Manager % Portfolio Activity Shares Value Report Date
0.16% Reduce -67.1% 492,346 $145.11 M Q4 2025
0.03% New Buy 66,230 $19.52 M Q4 2025
0.00% Add 31.6% 28,828 $8.5 M Q4 2025
0.60% Reduce -20.0% 8,400 $2.48 M Q4 2025
Date
Insider Name
Transaction
Value
Shares
Position / Chg
SEC Form