Renaissance Technologies (RenTech)'s RYTM Position Overview
Renaissance Technologies (RenTech) (via Renaissance Technologies LLC (Rentech)) currently holds 341,193 shares of Rhythm Pharmaceuticals, Inc. (RYTM) worth $36.52 M, representing 0.06% of the portfolio. First purchased in 2019-Q3, this medium-term investment has been held for 15 quarters.
Based on 13F filings, Renaissance Technologies (RenTech) has maintained a strategic position in RYTM, demonstrating sustained confidence in this investment. Largest addition occurred in Q2 2025, adding 300,781 shares. Largest reduction occurred in Q4 2025, reducing 205,400 shares.
Analysis based on 13F filings available since 2013 Q2
Renaissance Technologies (RenTech)'s Rhythm Pharmaceuticals (RYTM) Holding Value Over Time
Track share changes against reported price movement
Quarterly Rhythm Pharmaceuticals (RYTM) Trades by Renaissance Technologies (RenTech)
| Report Date | Bought/Sold (Sh.) | % Change | Qtr. End Shares | Reported Price |
|---|---|---|---|---|
| Q4 2025 | -205,400 | Reduce 37.58% | 341,193 | $107.04 |
| Q3 2025 | +231,700 | Add 73.58% | 546,593 | $100.99 |
| Q2 2025 | +300,781 | Add 2131.38% | 314,893 | $63.19 |
| Q1 2025 | +14,112 | New Buy | 14,112 | $52.97 |
| Q2 2022 | -23,100 | Sold Out | 0 | $0.00 |
| Q1 2022 | +23,100 | New Buy | 23,100 | $11.52 |
| Q3 2021 | -52,200 | Sold Out | 0 | $0.00 |
| Q2 2021 | +3,200 | Add 6.53% | 52,200 | $19.58 |
| Q1 2021 | +39,000 | Add 390.00% | 49,000 | $21.27 |
| Q4 2020 | -187,000 | Reduce 94.92% | 10,000 | $29.70 |
| Q3 2020 | -38,900 | Reduce 16.49% | 197,000 | $21.67 |
| Q2 2020 | +141,200 | Add 149.10% | 235,900 | $22.30 |
| Q1 2020 | +49,053 | Add 107.46% | 94,700 | $15.22 |
| Q4 2019 | +34,947 | Add 326.61% | 45,647 | $22.96 |
| Q3 2019 | +10,700 | New Buy | 10,700 | $21.59 |
Renaissance Technologies (RenTech)'s Rhythm Pharmaceuticals Investment FAQs
Renaissance Technologies (RenTech) first purchased Rhythm Pharmaceuticals, Inc. (RYTM) in Q3 2019, acquiring 10,700 shares, as reported in their 13F filing for that period. Note: Analysis reflects filings available since Q2 2013; earlier records may be incomplete.
Renaissance Technologies (RenTech) has held Rhythm Pharmaceuticals, Inc. (RYTM) for 15 quarters since Q3 2019.
Renaissance Technologies (RenTech)'s largest addition to Rhythm Pharmaceuticals, Inc. (RYTM) was in Q2 2025, adding 314,893 shares worth $19.9 M.
According to the latest 13F filing for Q4 2025, Renaissance Technologies (RenTech)'s firm, Renaissance Technologies LLC (Rentech), owns 341,193 shares of Rhythm Pharmaceuticals, Inc. (RYTM), valued at approximately $36.52 M.
As of the Q4 2025 filing, Rhythm Pharmaceuticals, Inc. (RYTM) represents approximately 0.06% of Renaissance Technologies (RenTech)'s publicly disclosed stock portfolio, making it one of their key holdings.
Renaissance Technologies (RenTech)'s peak holding in Rhythm Pharmaceuticals, Inc. (RYTM) was 546,593 shares, as reported at the end of Q3 2025.