Renaissance Technologies (RenTech)'s PBYI Position Overview
Renaissance Technologies (RenTech) (via Renaissance Technologies LLC) currently holds 1.84 M shares of Puma Biotechnology, Inc. (PBYI) worth $14.89 M, representing 0.02% of the portfolio. First purchased in 2014-Q1, this long-term strategic position has been held for 41 quarters.
Based on 13F filings since 2013, Renaissance Technologies (RenTech) has maintained a long-term strategic position in PBYI, representing a significant commitment to this investment thesis. Largest addition occurred in Q1 2020, adding 991,097 shares. Largest reduction occurred in Q3 2019, reducing 252,200 shares.
Analysis based on 13F filings available since 2013 Q2
Renaissance Technologies (RenTech)'s Puma Biotechnology (PBYI) Holding Value Over Time
Track share changes against reported price movement
Quarterly Puma Biotechnology (PBYI) Trades by Renaissance Technologies (RenTech)
| Report Date | Bought/Sold (Sh.) | % Change | Qtr. End Shares | Reported Price |
|---|---|---|---|---|
| Q2 2026 | -106,200 | Reduce 5.47% | 1.84 M | $8.11 |
| Q1 2026 | -181,400 | Reduce 8.54% | 1.94 M | $6.39 |
| Q4 2025 | -27,400 | Reduce 1.27% | 2.12 M | $5.95 |
| Q3 2025 | +276,500 | Add 14.75% | 2.15 M | $5.31 |
| Q2 2025 | +45,500 | Add 2.49% | 1.87 M | $3.43 |
| Q1 2025 | +73,700 | Add 4.20% | 1.83 M | $2.96 |
| Q4 2024 | -16,900 | Reduce 0.95% | 1.76 M | $3.05 |
| Q3 2024 | +19,400 | Add 1.11% | 1.77 M | $2.55 |
| Q2 2024 | +23,600 | Add 1.36% | 1.75 M | $3.26 |
| Q1 2024 | +56,200 | Add 3.36% | 1.73 M | $5.30 |
| Q4 2023 | -53,389 | Reduce 3.09% | 1.67 M | $4.33 |
| Q3 2023 | -31,411 | Reduce 1.79% | 1.73 M | $2.63 |
| Q2 2023 | -76,900 | Reduce 4.19% | 1.76 M | $0.00 |
| Q1 2023 | +136,070 | Add 8.01% | 1.83 M | $0.00 |
| Q4 2022 | -100,819 | Reduce 5.60% | 1.7 M | $0.00 |
| Q3 2022 | -177,273 | Reduce 8.97% | 1.8 M | $2.37 |
| Q2 2022 | +205,700 | Add 11.61% | 1.98 M | $2.85 |
| Q1 2022 | -49,623 | Reduce 2.73% | 1.77 M | $2.88 |
| Q4 2021 | +188,923 | Add 11.58% | 1.82 M | $3.04 |
| Q3 2021 | +33,600 | Add 2.10% | 1.63 M | $7.01 |
| Q2 2021 | +6,100 | Add 0.38% | 1.6 M | $9.18 |
| Q1 2021 | -69,200 | Reduce 4.17% | 1.59 M | $9.72 |
| Q4 2020 | +109,738 | Add 7.07% | 1.66 M | $10.26 |
| Q3 2020 | +86,000 | Add 5.87% | 1.55 M | $10.09 |
| Q2 2020 | +377,100 | Add 34.64% | 1.47 M | $10.43 |
| Q1 2020 | +991,097 | Add 1016.51% | 1.09 M | $8.44 |
| Q4 2019 | +97,500 | New Buy | 97,500 | $8.75 |
| Q3 2019 | -252,200 | Sold Out | 0 | $0.00 |
| Q2 2019 | +160,300 | Add 174.43% | 252,200 | $12.71 |
| Q1 2019 | -185,700 | Reduce 66.89% | 91,900 | $38.79 |
| Q4 2018 | +277,600 | New Buy | 277,600 | $20.35 |
| Q4 2017 | -134,600 | Sold Out | 0 | $0.00 |
| Q3 2017 | +134,600 | New Buy | 134,600 | $119.75 |
| Q2 2017 | -206,500 | Sold Out | 0 | $0.00 |
| Q1 2017 | +206,500 | New Buy | 206,500 | $37.20 |
| Q4 2015 | -162,600 | Sold Out | 0 | $0.00 |
| Q3 2015 | +162,600 | New Buy | 162,600 | $75.36 |
| Q4 2014 | -30,200 | Sold Out | 0 | $0.00 |
| Q3 2014 | +30,200 | New Buy | 30,200 | $238.58 |
| Q2 2014 | -12,600 | Sold Out | 0 | $0.00 |
| Q1 2014 | +12,600 | New Buy | 12,600 | $104.13 |
Renaissance Technologies (RenTech)'s Puma Biotechnology Investment FAQs
Renaissance Technologies (RenTech) first purchased Puma Biotechnology, Inc. (PBYI) in Q1 2014, acquiring 12,600 shares, as reported in their 13F filing for that period. Note: Analysis reflects filings available since Q2 2013; earlier records may be incomplete.
Renaissance Technologies (RenTech) has held Puma Biotechnology, Inc. (PBYI) for 41 quarters since Q1 2014.
Renaissance Technologies (RenTech)'s largest addition to Puma Biotechnology, Inc. (PBYI) was in Q1 2020, adding 1,088,597 shares worth $9.19 M.
According to the latest 13F filing for Q2 2026, Renaissance Technologies (RenTech)'s firm, Renaissance Technologies LLC, owns 1,836,213 shares of Puma Biotechnology, Inc. (PBYI), valued at approximately $14.89 M.
As of the Q2 2026 filing, Puma Biotechnology, Inc. (PBYI) represents approximately 0.02% of Renaissance Technologies (RenTech)'s publicly disclosed stock portfolio, making it one of their key holdings.
Renaissance Technologies (RenTech)'s peak holding in Puma Biotechnology, Inc. (PBYI) was 2,151,213 shares, as reported at the end of Q3 2025.